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ea0032p1002 | Thyroid (non-cancer) | ECE2013

Diagnosis of hypothyroidism is associated to an increased risk of acute decompensated heart failure occurrence, but not of mortality among heart failure outpatients

Triggiani Vincenzo , Iacoviello Massimo , Puzzovivo Agata , Antoncecchi Valeria , Angelo Giagulli Vito , Guastamacchia Edoardo , Favale Stefano

It has been demonstrated that hypothryoidism could affect the prognosis of patients with cardiovascular disease. The aim of this study was to better clarify the prognostic role of hypothyroidism in patients with chronic heart failure (CHF).We enrolled 384 consecutive outpatients (65±13 years, 296 males, NYHA 2.3±0.6, left ventricular ejection fraction, LVEF, 32±9%) with CHF (ESC criteria), in stable clinical conditions (at least 30 days) a...

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ea0081p355 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

GLP-1 receptor agonists and erectile dysfunction in diabetic men with and without hypogonadism: a 1- year retrospective observational study

Lisco Giuseppe , Isabella Ramunni Maria , De Pergola Giovanni , Jirillo Emilio , Guastamacchia Edoardo , Triggiani Vincenzo , Angelo Giagulli Vito

Background: Erectile dysfunction affects nearly half of men with type 2 diabetes (T2DM), and one-third of diabetic men have hypogonadism1. As an add-on to TRT in hypogonadal men with T2DM, Liraglutide may improve erectile function2, and dulaglutide decreased the incidence of moderate and severe ED in T2DM3.Study aims: To assess the GLP-1RA effect in T2DM men complaining of ED treated with both liraglutide and dulaglutide ...

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ea0090p209 | Thyroid | ECE2023

The TNAPP web-based algorithm improves thyroid nodule management in clinical practice. A retrospective validation study

Lisco Giuseppe , Renzulli Giuseppina , Frasoldati Andrea , Guglielmi Rinaldo , Angelo Giagulli Vito , Guastamacchia Edoardo , R Garber Jeffrey , Triggiani Vincenzo , Papini Enrico

The detection of thyroid nodules has been increasing over time, resulting in an extensive use of fine-needle aspiration (FNA) and cytology. Tailored methods are required to improve the management of thyroid nodules, including algorithms and web-based tools. To assess the performance of the Thyroid Nodule App (TNAPP), a web-based, interactive algorithmic tool, in improving the management of thyroid nodules, we carried out a preliminary analysis on a cohort of outpatients. One h...

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ea0090p61 | Diabetes, Obesity, Metabolism and Nutrition | ECE2023

The dual GIP/GLP-1 receptor co-agonist Tirzepatide vs GLP-1 receptor agonists as add-on to basal insulin in uncontrolled type 2 diabetes mellitus: A rapid review of randomized controlled trials and meta-analysis

Lisco Giuseppe , De Tullio Anna , Disoteo Olga , De Geronimo Vincenzo , Piazzolla Giuseppina , De Pergola Giovanni , Angelo Giagulli Vito , Jirillo Emilio , Guastamacchia Edoardo , Sabba Carlo , Triggiani Vincenzo

Tirzepatide, a once-weekly dual co-agonist of Glucose-Dependent Insulinotropic Polypeptide (GIP) and Glucagon-Like Peptide 1 (GLP-1) receptors, has been demonstrated to improve glucose control and reduced body weight in different therapeutic approaches. With this rapid review and meta-analysis, we systematically reviewed the efficacy and safety of injectable incretin-based therapy added to basal insulin compared to basal insulin plus background treatments titrated rigorously t...

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ea0049gp214 | Thyroid 2 | ECE2017

Thyroid hormones deficiencies and poor outcome in chronic heart failure outpatients

Triggiani Vincenzo , Licchelli Brunella , Terlizzese P , Grande D , Rizzo C , Lattarulo MS , Leopizzi T , Gioia I , Angelo Giagulli Vito , Guastamacchia Edoardo , Iacoviello Massimo

Background: Hypothyroidism and low T3 syndrome frequently occur in HF patients.Aim of the study: To evaluate in a large sample of CHF patients the association between thyroid hormone deficiencies and poor outcome.Methods and results: From 2006 to 2015, we screened 712 consecutive CHF outpatients (551 males, 64±14 years, left ventricular ejection fraction (LVEF) 33±10%, NYHA class 2.3±0.6, NTproBNP 2153±4696 pg/m...